FWIW, I would sure as shit hope that you can get >22 mpg combined with that engine, since a stock LS1 will do better than that in an RX7.
Beyond that, it looks difficult to fit by the pan design, but you can sure give it a try. Make sure you have lots of time, money and skill, or just lots of time and money to pay someone else to figure it out. That's direct injection, right? Gonna have to figure out a fuel system.
Looks pie in the sky to me, but good luck if you go through with it.